cytoNet: Spatiotemporal Network Analysis of Cell Communities

• Published in: bioRxiv
• Main Authors: Mahadevan, Arun S, Long, Byron L, Hu, Chenyue W, Ryan, David T, Grandel, Nicolas E, Maloney, Zacharie, Britton, George L, Gonzalez Porras, Maria A, Stojkova, Katerina, Ligeralde, Andrew, Son, Hyeonwi, Shannonhouse, John, Robinson, Jacob T, Warmflash, Aryeh, Brey, Eric, Yu Shin Kim, Qutub, Amina A
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.02.2021
• Subjects: Brain injury; Cell cycle; Cell differentiation; Cell interactions; Endothelial cells; Environmental effects; Neural stem cells; Neurotrophic factors; Phenotypes; Progenitor cells; Regenerative medicine

Abstract We introduce cytoNet, a cloud-based tool to characterize cell populations from microscopy images. cytoNet quantifies spatial topology and functional relationships in cell communities using principles of network science. Capturing multicellular dynamics through graph features, cytoNet also e...