Protein Kinase A Negatively Regulates Ca2+ signalling in Toxoplasma gondii

• Published in: bioRxiv
• Main Authors: Uboldi, Alessandro D, Wilde, Mary-Louise, Mcrae, Emi A, Stewart, Rebecca J, Dagley, Laura F, Yang, Luning, Katris, Nicholas J, Hapuarachchi, Sanduni V, Coffey, Michael J, Lehane, Adele M, Botte, Cyrille Y, Waller, Ross F, Webb, Andrew I, Tonkin, Christopher J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.02.2018
• Subjects: Acylation; Calcium signalling; Cyclic AMP; Cyclic GMP; Infectivity; Intracellular; Kinases; Motility; Parasites; Perforin; Protein kinase A; Proteins; Secretion

The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating forms and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motility, but how this is switched off after invasion is...