Addition of Genetics to Quantitative MRI Facilitates Earlier Prediction of Dementia: A Non-invasive Alternative to Amyloid Measures

• Published in: bioRxiv
• Main Authors: Schenker-Ahmed, Natalie M, Bulsara, Nafisa, Yang, Lei, Huang, Lei, Arya Iranmehr, Wu, Jian, Graff, Alexander M, Dadakova, Tetiana, Hyun-Kyung Chung, Tkach, Dmitry, Shomorony, Ilan, Shah, Naisha, Garst, Peter, Heister, Robyn, Bureeva, Svetlana, Delport, Wayne, Karow, David S, Brewer, James B, Swisher, Christine L
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.08.2019
• Subjects: Alzheimer's disease; Cerebrospinal fluid; Dementia; Dementia disorders; Genome-wide association studies; Genomes; Image processing; Magnetic resonance imaging; Medical imaging; Neural networks; Neurodegenerative diseases; Neuroimaging; Positron emission tomography; Regression analysis; Risk assessment; Risk groups; Segmentation; Survival; Survival analysis

Background: Alzheimer's disease is a major health problem, affecting ~4.5% of people aged 60 and older in 2016 with over 43 million affected globally. The traditional approach for detection evaluates an individual in the presence of symptoms. However, it has been established that amyloid deposi...