Splicing buffers suboptimal codon usage in human cells

• Published in: bioRxiv
• Main Authors: Mordstein, Christine, Savisaar, Rosina, Young, Robert S, Bazile, Jeanne, Talmane, Lana, Luft, Juliet, Liss, Michael, Taylor, Martin S, Hurst, Laurence D, Kudla, Grzegorz
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 22.01.2019
• Subjects: Adenine; Cytosine; Exons; Gene expression; Genomes; Guanine; Introns; Localization; Splicing; Thymine

Although multiple studies have addressed the effects of codon usage on gene expression, such studies were typically performed in unspliced model genes. In the human genome, most genes undergo splicing and patterns of codon usage are splicing-dependent: guanine and cytosine (GC) content is highest wi...