Islet vascularization is regulated by primary endothelial cilia via VEGF-A dependent signaling

• Published in: bioRxiv
• Main Authors: Xiong, Yan, Scerbo, M Julia, Seelig, Anett, Volta, Francesco, O'brien, Nils, Dicker, Andrea, Padula, Daniela, Lickert, Heiko, Gerdes, Jantje M, Berggren, Per-Olof
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.06.2019
• Subjects: Angiogenesis; Anterior chamber; Cell proliferation; Cilia; Electron microscopy; Endothelial cells; Glucose; Homeostasis; Insulin; Insulin secretion; Internalization; Pancreatic islet transplantation; Permeability; Phenotypes; Secretion; Signal transduction; Vascular endothelial growth factor; Vascularization

Rationale Accumulating evidence point to a role for primary cilia in endothelial cell function. Islet vascularization is an important determinant of islet function and glucose homeostasis. We have previously shown that β-cell cilia directly regulate insulin secretion. However, it is unclear whether...