NOD2 contributes to cutaneous defense against Staphylococcus aureus through [alpha]-toxin-dependent innate immune activation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 31; pp. 12873 - 12878
• Main Authors: Hruz, Petr, Zinkernagel, Annelies S, Jenikova, Gabriela, Botwin, Gregory J, Hugot, Jean-Pierre, Karin, Michael, Nizet, Victor, Eckmann, Lars
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 04.08.2009
• Subjects: Bacteria; Cytokines; Nosocomial infection; Pathogens; Peptides; Physiology; Rodents; Staphylococcus aureus; Staphylococcus infections; T cell receptors; Toxins

Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal component...