Impaired translation of CCAAT/enhancer binding protein a mRNA in bronchial smooth muscle cells of asthmatic patients

• Published in: Journal of allergy and clinical immunology Vol. 123; no. 3; pp. 639 - 645
• Main Authors: BORGER, Peter, MIGLINO, Nicola, BARAKET, Melissa, BLACK, Judith L, TAMM, Michael, ROTH, Michael
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 01.03.2009; Elsevier Limited
• Subjects: Asthma; Biological and medical sciences; Chronic obstructive pulmonary disease, asthma; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Genotype & phenotype; Immunopathology; Kinases; Medical sciences; Pathology; Peptides; Pneumology; Proteins; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Smooth muscle; Human; Lung disease; Immunopathology; C/EBPα; Respiratory disease; Hyperplasia; Bronchus; Smooth muscle; bronchial smooth muscle cell hyperplasia; Respiratory system; Genetic translation; Asthma; C/EBP transcription factor; Myocyte; messenger RNA translation; Respiratory tract; Binding protein; Immunology; Messenger RNA; Bronchus disease; Obstructive pulmonary disease

Background Bronchial smooth muscle (BSM) cells of asthmatic patients have an impaired expression of CCAAT/enhancer binding protein (C/EBP) α, which is associated with increased proliferation. Objective We sought to assess the translational regulation ofCEBPAmRNA in cultured BSM cells of healthy cont...