Functional map of TEA transport activity in isolated rabbit renal proximal tubules

• Published in: American journal of physiology. Renal physiology Vol. 56; no. 3; pp. F442 - F451
• Main Authors: WRIGHT, Stephen H, EVANS, Kristen K, XIAOHONG ZHANG, CHERRINGTON, Nathan J, SITAR, Daniel S, DANTZLER, William H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.09.2004
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Kidneys; Pharmacology; Toxicology; Vertebrates: urinary system; Biological transport; Cimetidine; Rabbit; Lagomorpha; Antihistaminic; Kidney; organic cation transporter 1; organic cation transporter 2; Vertebrata; Renal tubule; Mammalia; Urinary system; tetraethylammonium; Cations; organic cation; Antagonist; Proximal tube; H2 Histamine receptor; Carrier protein

The organic cation (OC) transporters OCT1 and OCT2 are suspected of mediating substrate entry from the blood into proximal tubule cells as the first step in renal secretion of OCs. We examined the contribution of each process in different rabbit renal proximal tubule (RPT) segments, taking advantage...