Inhibition of PLC improves postischemic recovery in isolated rat heart

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 56; no. 6; pp. H2598 - H2605
• Main Authors: ASEMU, Girma, DHALLA, Naranjan S, TAPPIA, Paramjit S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.12.2004
• Subjects: Biological and medical sciences; Blood pressure; Calcium; Drug therapy; Fundamental and applied biological sciences. Psychology; Heart; Heart attacks; Phosphates; Vertebrates: cardiovascular system; Heart; Sarcolemma; Rat; Calcium antagonist; Rodentia; U-73122; Cardiovascular disease; Recovery; Vertebrata; Mammalia; Ischemia; Aralkylamine; Verapamil; Circulatory system; Hemodynamics; Inhibition

The Ca2+-dependent PLC converts phosphatidylinositol 4,5-bisphosphate to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Because these products modulate Ca2+ movements in the myocardium, PLC may also contribute to a self-perpetuating cycle that exacerbates cardiomyocyte Ca2+-ov...