An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans

Hepatic glucose synthesis from glycogen, glycerol, and the tricarboxylic acid (TCA) cycle was measured in five overnight-fasted subjects by (1)H, (2)H, and (13)C NMR analysis of blood glucose, urinary acetaminophen glucuronide, and urinary phenylacetylglutamine after administration of [1,6-(13)C2]gl...

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Published inAmerican journal of physiology: endocrinology and metabolism Vol. 44; no. 4; pp. E848 - E856
Main Authors JONES, John G, SOLOMON, Michael A, COLE, Suzanne M, SHERRY, A. Dean, MALLOY, Craig R
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.10.2001
Subjects
Biological and medical sciences
Carbohydrates
Fundamental and applied biological sciences. Psychology
Glucose
Liver
Metabolism
Metabolisms and neurohumoral controls
NMR
Nuclear magnetic resonance
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Human
Digestive system
Liver
Metabolic pathway
Glucose
Metabolism
Gluconeogenesis
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Summary:Hepatic glucose synthesis from glycogen, glycerol, and the tricarboxylic acid (TCA) cycle was measured in five overnight-fasted subjects by (1)H, (2)H, and (13)C NMR analysis of blood glucose, urinary acetaminophen glucuronide, and urinary phenylacetylglutamine after administration of [1,6-(13)C2]glucose, (2)H2O, and [U-(13)C3]propionate.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ISSN:0193-1849
1522-1555