Tetracycline-inducible gene expression in cultured rat renal CD cells and in intact CD from transgenic mice

• Published in: American journal of physiology. Renal physiology Vol. 50; no. 6; pp. F1164 - F1172
• Main Authors: PUTTINI, Stefania, BEGGAH, Ahmed T, OUVRARD-PASCAUD, Antoine, LEGRIS, Christine, BLOT-CHABAUD, Marcel, FARMAN, Nicolette, JAISSER, Frederic
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.12.2001
• Subjects: Biological and medical sciences; Cellular biology; Fundamental and applied biological sciences. Psychology; Genes; Kidneys; Pathology; Rodents; Vertebrates: urinary system; Animal model; Pathophysiology; Rodentia; Transgenic animal; Gene expression; In vitro; Kidney; Tetracycline; Vertebrata; Mammalia; Cell line; Urinary system; Mouse; Collecting duct; Renal cortex

The renal collecting duct (CD) plays a key role in the control of ion and fluid homeostasis. Several genetic diseases that involve mutations in genes encoding for ion transporters or hormone receptors specifically expressed in CD have been described.