A Dot/lcm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa

• Published in: Molecular microbiology Vol. 70; no. 4; pp. 908 - 923
• Main Authors: AL-KHODOR, Soulaila, PRICE, Christopher T, HABYARIMANA, Fabien, KALIA, Awdhesh, ABU KWAIK, Yousei
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Science 01.11.2008; Blackwell Publishing Ltd
• Subjects: Bacteria; Bacteriology; Biochemistry; Biological and medical sciences; Cellular biology; Eukaryotes; Fundamental and applied biological sciences. Psychology; Microbiology; Miscellaneous; Proteins; Protozoa; Human; Cell proliferation; Membrane protein; Legionellaceae; Microbiology; Bacteria; Legionella pneumophila; Ankyrin; Intracellular; Macrophage

The Dot/Icm type IV secretion system of Legionella pneumophila translocates numerous bacterial effectors into the host cell and is essential for bacterial proliferation within macrophages and protozoa. We have recently shown that L. pneumophila strain AA100/130b harbours 11 genes encoding eukaryotic...