Permissive role of nitric oxide in macula densa control of renin secretion

• Published in: American journal of physiology. Renal physiology Vol. 55; no. 5; pp. F848 - F857
• Main Authors: CASTROP, Hayo, SCHWEDA, Frank, MIZEL, Diane, YUNING HUANG, BRIGGS, Josie, KURTZ, Armin, SCHNERMANN, Jurgen
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.05.2004
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Kidneys; Nitric oxide; Proteases; Rodents; Vertebrates: urinary system; Sulfanilamide derivatives; perfused kidney; neuronal nitric oxide synthase knockout; endothelial nitric oxide synthase knockout; furosemide; bumetanide; Sulfonamide; Enzyme; Secretion; plasma renin; isolated; Furosemide; Nitric-oxide synthase; Kidney; Peptidases; Vertebrata; Mammalia; Renin; Urinary system; Nitric oxide; Anthranilic acid derivatives; Hydrolases; Aspartic endopeptidases; Oxidoreductases; Mutation; Bumetanide; Macula densa

Experiments were performed in neuronal (nNOS)- and endothelial nitric oxide synthase (eNOS)-deficient mice to study the role of nitric oxide (NO) in macula densa control of renin secretion in vivo and in the isolated, perfused mouse kidney. Acute and chronic administration of loop diuretics was used...