Metabolic and cardiorespiratory responses to the lactate clamp

• Published in: American journal of physiology: endocrinology and metabolism Vol. 46; no. 5; pp. E889 - E898
• Main Authors: MILLER, Benjamin F, FATTOR, Jill A, JACOBS, Kevin A, HORNING, Michael A, SUH, Sang-Hoon, NAVAZIO, Franco, BROOKS, George A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.11.2002
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; General aspects; Glucose; Kinetics; Metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Physical exercise; Physical training; Bicycle ergometer; Environmental factor; Oxygen consumption; Male; Glucose; Metabolism; Heart rate; Lactates; Young adult; Arterial pressure; Carbohydrate; Circulatory system; Hemodynamics; Kinetics; Gluconeogenesis

To evaluate the hypothesis that precursor supply limits gluconeogenesis (GNG) during exercise, we examined training-induced changes in glucose kinetics [rates of appearance (Ra) and disappearance (Rd)], oxidation (Rox), and recycling (Rr) with an exogenous lactate infusion to 3.5-4.0 mM during rest...