NF-κ B mediates the effect of glucosylceramide synthase on P-glycoprotein modulation in a drug-resistance leukemia cell line

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 31; no. 1; p. 34
• Main Authors: Zhang, Xiufen, Xie, Keming, Zou, Jian, Li, Yuling, Mu, Huijun, Zhang, Bin, Xie, Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2014
• Subjects: ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucosyltransferases - genetics; Glucosyltransferases - metabolism; Humans; K562 Cells; Leukemia - genetics; NF-kappa B - genetics; NF-kappa B - metabolism

To investigate whether transcription factor-kappaB (NF-κ B) is involved in the modulation of P-glycoprotein (P-gp) by glucosylceramide synthase (GCS) in a multidrug resistance leukemia cell line K562/A02 and to explore the relationship between NF-κ B and extracelluar signal-regulated kinase (ERK). K...