REDUCED DNASE ENZYME ACTIVITY IN RESPONSE TO HIGH POST-INJURY MITOCHONDRIAL DNA CONCENTRATION PROVIDES A THERAPEUTIC TARGET FOR SIRS

• Published in: The journal of trauma and acute care surgery
• Main Authors: McIlroy, Daniel J, Minahan, Kyra, Keely, Simon, Lott, Natalie, Hansbro, Philip, Smith, Doug W, Balogh, Zsolt J
• Format: Journal Article
• Language: English
• Published: United States 22.03.2018

Cell free mitochondrial DNA (mtDNA) is pro-inflammatory and has been detected in high concentrations in trauma patients' plasma. Deoxyribonuclease (DNase) is the free plasma enzyme responsible for the digestion of extracellular DNA. The relationship between mtDNA and DNase after major trauma is...