Natural selection and functional diversification of the epidermal growth factor receptor EGFR family in vertebrates

• Published in: Genomics (San Diego, Calif.) Vol. 101; no. 6; p. 318
• Main Authors: Liu, Yong, He, Wenwu, Long, Jianxiong, Pang, Feng, Xian, Lei, Chen, Mingwu, Wu, Yaosheng, Hu, Yanling
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Amino Acid Sequence; Animals; Evolution, Molecular; Gene Duplication; Genes, erbB-1; Molecular Sequence Data; Phylogeny; Receptor, Epidermal Growth Factor - chemistry; Receptor, Epidermal Growth Factor - genetics; Selection, Genetic; Vertebrates - genetics

Genes that have been subject to adaptive evolution can produce varying degrees of pathology or differing symptomatology. ErbB family receptor activation will initiate a number of downstream signaling pathways, such as mitogen-activated protein kinase (MAPK), activator of transcription (STAT), the mo...