Molecular mechanisms of cell death in the retina during the development of age-related macular degeneration

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 29; no. 3; p. 424
• Main Authors: Telegina, D V, Kozhevnikova, O S, Kolosova, N G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Bruch Membrane - metabolism; Cell Death - physiology; Humans; Macular Degeneration - metabolism; Macular Degeneration - physiopathology; Retinal Pigment Epithelium - metabolism; apoptosis; autophagy; retina; age-related macular degeneration; necroptosis

Age-related macular degeneration (AMD) is a chronic progressive disease characterized by lesions in the central area of the retina. The pathogenesis of AMD involves aging-associated changes in the choriocapillaris, retinal pigment epithelium (RPE), and in Bruch's membrane, but the mechanisms th...