Basic research of fibrosis on atherosclerotic plaque stability and related drug application

• Published in: Zhongguo zhongyao zazhi Vol. 44; no. 2; p. 235
• Main Authors: Yin, Jie, Li, Qi, Zhao, Zheng, Yang, Qing, Li, Yu-Jie, Chen, Ying, Wang, Ya-Jie, Weng, Xiao-Gang, Cai, Wei-Yan, Zhu, Xiao-Xin
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2019
• Subjects: Atherosclerosis - drug therapy; Atherosclerosis - pathology; Cytokines; Fibrosis; Humans; Inflammation; Plaque, Atherosclerotic - drug therapy; Plaque, Atherosclerotic - pathology; Thrombosis - drug therapy; Thrombosis - pathology; atherosclerosis; inflammation regulation; fibrosis; drug application; plaque stability
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20181012.005

In the background of the high incidence and high mortality of cardiovascular diseases,atherosclerosis is the main pathological feature of cardiovascular diseases and the core pathological basis for disease progression. In the evolution of atherosclerotic plaques,the rupture of unstable plaques,plaque shedding and formation of thrombosis are the most dangerous parts. In this process,the formation of plaque fibrosis is the core mechanism regulating plaque stability. Additionally,fibrosis reflects dynamic changes in the inflammatory processes and pathological changes. In view of the inflammation regulation and fibrosis regulation,this paper clarified the process of atherosclerotic plaque,explained the roles of relevant inflammatory cells and cytokines in plaque stability,and summed up drug researches related with stable plaque in recent years. In the future,improving the fibrosis will be a new idea for stabilizing plaque in atherosclerosis drug development.