Primary biliary cholangitis. Part 1. State of the art, epidemiology, physiopathology and clinical manifestations

• Published in: Revista de gastroenterología del Perú Vol. 37; no. 4; pp. 357 - 364
• Main Authors: Rodríguez Lugo, Diego Andrés, Coronado Tovar, Jorge Julián, Solano Villamarin, Giovana Alejandra, Otero Regino, Wiliam
• Format: Journal Article
• Language: Spanish
• Published: Peru 01.10.2017
• Subjects: Antibody Specificity; Autoantibodies - immunology; Autoimmune Diseases - epidemiology; Autoimmune Diseases - physiopathology; Bile Acids and Salts - metabolism; Cholangitis - complications; Cholangitis - epidemiology; Cholangitis - immunology; Cholangitis - physiopathology; Fatigue - etiology; Genetic Predisposition to Disease; Humans; Liver Cirrhosis, Biliary - etiology; Liver Cirrhosis, Biliary - prevention & control; Microbiota; Mitochondria - immunology; Pruritus - etiology; Smoking - adverse effects; Urinary Tract Infections - complications; Ursodeoxycholic Acid - therapeutic use

Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may...