Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in respo...

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Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 48; no. 1; pp. H1 - H6
Main Authors ROBINSON, R, IIDA, H, O'BRIEN, T. P, PANE, M. A, TRAYSTMAN, R. J, GLEASON, C. A
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.07.2000
Subjects
Biological and medical sciences
Brain
Circulatory system
Cocaine
Drug addictions
Medical sciences
Oxygen
Toxicology
Regional blood flow
Drug addiction
Intravenous administration
Toxicity
Central nervous system
Oxygen consumption
Vasodilation
Ester
Vasomotricity
Vertebrata
Mammalia
Vascular resistance
Newborn animal
Adult animal
Development
Fetus
Sheep
Cocaine
Drug of abuse
Artiodactyla
Hemodynamics
Ungulata
Brain (vertebrata)
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Summary:Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in responses to cocaine, we compared the cerebrovascular and metabolic responses to a 2 mg/kg iv cocaine dose in unanesthetized fetal (n = 8, previously reported, direct fetal injection), newborn (n = 6), and adult (n = 12) sheep.
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ISSN:0363-6135
1522-1539