Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 48; no. 1; pp. H1 - H6
• Main Authors: ROBINSON, R, IIDA, H, O'BRIEN, T. P, PANE, M. A, TRAYSTMAN, R. J, GLEASON, C. A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.07.2000
• Subjects: Biological and medical sciences; Brain; Circulatory system; Cocaine; Drug addictions; Medical sciences; Oxygen; Toxicology; Regional blood flow; Drug addiction; Intravenous administration; Toxicity; Central nervous system; Oxygen consumption; Vasodilation; Ester; Vasomotricity; Vertebrata; Mammalia; Vascular resistance; Newborn animal; Adult animal; Development; Fetus; Sheep; Cocaine; Drug of abuse; Artiodactyla; Hemodynamics; Ungulata; Brain (vertebrata)
• ISSN: 0363-6135

Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in responses to cocaine, we compared the cerebrovascular and metabolic responses to a 2 mg/kg iv cocaine dose in unanesthetized fetal (n = 8, previously reported, direct fetal injection), newborn (n = 6), and adult (n = 12) sheep.