SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms

• Published in: Molekuliarnaia biologiia Vol. 52; no. 5; p. 817
• Main Authors: Yin, Z, Zhang, K, Peng, X, Jiang, Z, Yuan, W, Wang, Y, Li, Y, Ye, X, Dong, Y, Wan, Y, Ni, B, Zhu, P, Fan, X, Wu, X, Mo, X
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2018
• Subjects: Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins - chemistry; Cloning, Molecular; DNA-Binding Proteins - chemistry; Humans; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Protein Isoforms - chemistry; Ubiquitination; protein interaction; SIVA1; alternative splicing; ubiquitination; SSBP3

The assembly of LIM-homeodomain (LIM-HD) transcriptional complex plays important roles in early neuronal development. The stability of LIM-HD is controlled by single-strand binding protein 3 (SSBP3) via a cascade mechanism protecting it from proteasomal degradation. The expression level of SSBP3 has...