Effect of selank on the main carboxypeptidases in the rat nervous tissue

Effect of single selank administration on activity of carboxypeptidase H and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase - enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has been shown to cause...

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Bibliographic Details
Published inŽurnal ėvolûtsionnoj biohimii i fiziologii Vol. 48; no. 3; p. 254
Main Authors Solov'ev, V B, Gengin, M T, Sollertinskaia, T N, Latynova, I V, Zhivaeva, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2012
Subjects
Adrenal Glands - drug effects
Adrenal Glands - metabolism
Animals
Brain - drug effects
Brain - metabolism
Carboxypeptidase H - metabolism
Male
Neuropeptides - metabolism
Oligopeptides - administration & dosage
Rats
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Summary:Effect of single selank administration on activity of carboxypeptidase H and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase - enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has been shown to cause long, preserved for 24 h changes of activities of these carboxypeptidases. It is suggested that the change in activity of the studied enzymes can be one of mechanisms of regulation of level of neuropeptides at action of selank.
ISSN:0044-4529