AL Amyloidosis

• Published in: Brain and nerve = Shinkei kenkyū no shinpo Vol. 77; no. 8; p. 847
• Main Authors: Ide, Toshihiro, Koike, Haruki
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.08.2025
• Subjects: Humans; Immunoglobulin Light-chain Amyloidosis - diagnosis; Immunoglobulin Light-chain Amyloidosis - therapy; Peripheral Nervous System Diseases - diagnosis; Peripheral Nervous System Diseases - etiology

AL amyloidosis is a systemic disease caused by misfolded immunoglobulin light chains deposited as amyloid fibrils in multiple organs. Peripheral neuropathy, which often presents with sensory dissociation and autonomic dysfunction, is a key initial manifestation that can occasionally be misdiagnosed...