Biomonitoring of Work with Genotoxic Substances and Factors in a Cancer Treatment Facility
A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects. A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them...
Saved in:
Published in | Klinická onkologie Vol. 31; no. Supplementum1; p. 163 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | Czech |
Published |
Czech Republic
2018
|
Online Access | Get more information |
Cover
Loading…
Abstract | A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects.
A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them repeatedly) in a cancer treatment facility. The control group consisted of 119 persons excluded from the risk exposure. Fluorescence in situ hybridization with three pairs of whole-chromosomal probes and a pancrossomeric probe was used and the translocation frequency was determined.
The total number of chromosomal rearrangements of healthcare professionals and control group correlates with age. Taking into account the age dependence, an increased level of chromosomal reconstruction was found in the case of 11 individuals, 10 of which were female, working on the positions of pharmacist, general nurse, physician. A total of 9 of those case involved the work with cytostatics. Five of these cases were re-examined two years later and the observed levels dropped to the control level.
The results of biomonitoring should be evaluated on a group basis and individually, taking into account the personal history and possible non-professional effects on individuals - in particular those related to specific environmental measurement results.Key words: preventive medicine - occupational exposure - cytostatic agents - chromosome aberrations - in situ hybridization - fluorescence The authors declare they have no potential conflicts of interest concern ing drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers. This work was supported by project of Ministry of Health Czech Republic. reg. No. 15-33968A.Submitted: 12. 4. 2018Accepted: 16. 4. 2018. |
---|---|
AbstractList | A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects.
A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them repeatedly) in a cancer treatment facility. The control group consisted of 119 persons excluded from the risk exposure. Fluorescence in situ hybridization with three pairs of whole-chromosomal probes and a pancrossomeric probe was used and the translocation frequency was determined.
The total number of chromosomal rearrangements of healthcare professionals and control group correlates with age. Taking into account the age dependence, an increased level of chromosomal reconstruction was found in the case of 11 individuals, 10 of which were female, working on the positions of pharmacist, general nurse, physician. A total of 9 of those case involved the work with cytostatics. Five of these cases were re-examined two years later and the observed levels dropped to the control level.
The results of biomonitoring should be evaluated on a group basis and individually, taking into account the personal history and possible non-professional effects on individuals - in particular those related to specific environmental measurement results.Key words: preventive medicine - occupational exposure - cytostatic agents - chromosome aberrations - in situ hybridization - fluorescence The authors declare they have no potential conflicts of interest concern ing drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers. This work was supported by project of Ministry of Health Czech Republic. reg. No. 15-33968A.Submitted: 12. 4. 2018Accepted: 16. 4. 2018. |
Author | Brhel, P Hradská, H Musilová, P Svoboda, M Vozdová, M Petrovová, M Selingerová, I Goněc, R Kadlčíková, D Rubeš, J |
Author_xml | – sequence: 1 givenname: M surname: Petrovová fullname: Petrovová, M – sequence: 2 givenname: P surname: Musilová fullname: Musilová, P – sequence: 3 givenname: M surname: Svoboda fullname: Svoboda, M – sequence: 4 givenname: I surname: Selingerová fullname: Selingerová, I – sequence: 5 givenname: R surname: Goněc fullname: Goněc, R – sequence: 6 givenname: H surname: Hradská fullname: Hradská, H – sequence: 7 givenname: D surname: Kadlčíková fullname: Kadlčíková, D – sequence: 8 givenname: M surname: Vozdová fullname: Vozdová, M – sequence: 9 givenname: P surname: Brhel fullname: Brhel, P – sequence: 10 givenname: J surname: Rubeš fullname: Rubeš, J |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29808695$$D View this record in MEDLINE/PubMed |
BookMark | eNo1j8FKAzEYhHOo2Fr7CpIXWMimTXb3qIutQsGDC4qX8if5o9FusiQp2rd3i3UuA_MNA3NFJj54nJAZqyUvVo14nZJFSp9slOSVEPUlmfKmHnEjZuTtzoU-eJdDdP6dBktfQvyi3y5_0A36kMOP0_T5oFIGrzFR8IauQY_9RJ2nQNtTHmkXEXKPPp-o27t8vCYXFvYJF2efk25937UPxfZp89jebotBSFFUjao1M6VWmpdqKQWUyBoumAZdCaOXVjAsLQcrbakMQgXWjre0ESsrEfmc3PzNDgfVo9kN0fUQj7v_j_wXsx1RNw |
ContentType | Journal Article |
DBID | NPM |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
DocumentTitleAlternate | Biomonitoring práce s genotoxickými látkami a faktory v onkologickém zdravotnickém zařízení |
ExternalDocumentID | 29808695 |
Genre | English Abstract Journal Article |
GroupedDBID | 53G 6RF ALMA_UNASSIGNED_HOLDINGS EN8 F5P NPM OK1 |
ID | FETCH-LOGICAL-p565-79b8c0d1cbc21b365a1e09250cac75dc3f50e1f2af6f1bdea7aff495cd54f6ee2 |
ISSN | 0862-495X |
IngestDate | Sat Sep 28 08:36:23 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Supplementum1 |
Language | Czech |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p565-79b8c0d1cbc21b365a1e09250cac75dc3f50e1f2af6f1bdea7aff495cd54f6ee2 |
PMID | 29808695 |
ParticipantIDs | pubmed_primary_29808695 |
PublicationCentury | 2000 |
PublicationDate | Spring 2018 |
PublicationDateYYYYMMDD | 2018-01-01 |
PublicationDate_xml | – year: 2018 text: Spring 2018 |
PublicationDecade | 2010 |
PublicationPlace | Czech Republic |
PublicationPlace_xml | – name: Czech Republic |
PublicationTitle | Klinická onkologie |
PublicationTitleAlternate | Klin Onkol |
PublicationYear | 2018 |
SSID | ssj0000627558 |
Score | 2.0980837 |
Snippet | A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic,... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 163 |
Title | Biomonitoring of Work with Genotoxic Substances and Factors in a Cancer Treatment Facility |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29808695 |
Volume | 31 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3NT9swFMCtwS5cEGjja4B82K0KqlPHiY-s4mOb1ks7qdoF-VOqoHFVsgrx1-_ZTtMUDQRcrMgviZL8nJfnF7_3EPpqMk19-ZskN1ImtFfQRMicJSwV8LnkjHPtHfq_Buz6N_0xzsarZWMhuqSSZ-rxv3El76EKfcDVR8m-gWxzUuiAbeALLRCG9lWMv03cNLyT83rtsnd9R9fqlSld5R4mKqiGyrON2Zgv6wI7k7IjOn3fP--MmtXmIPWLZdf-9f4MwZO34Zc66bjyNuhLs1Kq1dwt3CLK1xysvoj0XVvSBJMNF046Ldb2HobQeDNvH_C97ZUgRcsrUSsvH43Fs3Fb0_ZIa0SFqqXBBfp3SloqlESF18I3mwZ-KS_grLEk58vSJxm0l6INtJEXXgsOao9O_FqneRbKuDaX7BNE14c8mWwEo2O0g7br2QI-j-h30Qd1_wn9WcOOncUeO_bYcYMdr7BjwI5r7HhSYoEjdtxgx0vsn9Ho8mLUv07qEhnJDCzxJOeyUF1NlFQpkT2WCWK6HKxaJVSeadWzWdcQmwrLLJHaiFxYC7eodEYtMybdQ5ulK80BwppJblNiWFeDkScpV4b7ZIOaU6o1lYdoPz6Jm1lMg3KzfEZHz0q-oK3V2DhGHy28d-YEjLhKngYK_wCXE0pN |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biomonitoring+of+Work+with+Genotoxic+Substances+and+Factors+in+a+Cancer+Treatment+Facility&rft.jtitle=Klinick%C3%A1+onkologie&rft.au=Petrovov%C3%A1%2C+M&rft.au=Musilov%C3%A1%2C+P&rft.au=Svoboda%2C+M&rft.au=Selingerov%C3%A1%2C+I&rft.date=2018-01-01&rft.issn=0862-495X&rft.volume=31&rft.issue=Supplementum1&rft.spage=163&rft_id=info%3Apmid%2F29808695&rft_id=info%3Apmid%2F29808695&rft.externalDocID=29808695 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0862-495X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0862-495X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0862-495X&client=summon |