Anti-ribosomal-phosphoprotein autoantibodies penetrate to neuronal cells via neuronal growth associated protein, affecting neuronal cells in vitro

• Published in: Rheumatology (Oxford, England)
• Main Authors: Kivity, Shaye, Shoenfeld, Yehuda, Arango, Maria-Teresa, Cahill, Dolores J, O'Kane, Sara Louise, Zusev, Margalit, Slutsky, Inna, Harel-Meir, Michal, Chapman, Joab, Matthias, Torsten, Blank, Miri
• Format: Journal Article
• Language: English
• Published: England 06.05.2016
• Subjects: neuropsychiatric-systemic lupus erythemathosus; anti-ribosomal antibodies; penetration; autoantibodies; brain cDNA library

Anti-ribosomal-phosphoprotein antibodies (anti-Ribos.P Abs) are detected in 10-45% of NPSLE patients. Intracerebroventricular administration of anti-ribosomal-P Abs induces depression-like behaviour in mice. We aimed to discern the mechanism by which anti-Ribos.P Abs induce behavioural changes in mi...