Effect of Selenious Yeast Tablets on the Thyroglobulin Antibody Level in ThyroglobulinAntibody-positive Patients with Differentiated Thyroid Cancer

To investigate the change of thyroglobulin antibodies (TgAb) after the application of selenious yeast tablet (SYT) in differentiated thyroid cancer (DTC) patients with positive TgAb (>115 U/ml). We enrolled 41 DTC patients with positive TgAb who had undergone total thyroidectomy and subsequent ¹³...

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Published inZhōngguó yīxué kēxuéyuàn xuébào Vol. 37; no. 5; p. 591
Main Authors Cong, Hui, Li, Hui, Liang, Jun, Yang, Ke, Zhao, Teng, Qiu, Wen-sheng, Lin, Yan-song
Format Journal Article
LanguageChinese
Published China 01.10.2015
Subjects
Adenocarcinoma
Autoantibodies
Humans
Tablets
Thyroglobulin
Thyroid Neoplasms
Thyroidectomy
Yeasts
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Summary:To investigate the change of thyroglobulin antibodies (TgAb) after the application of selenious yeast tablet (SYT) in differentiated thyroid cancer (DTC) patients with positive TgAb (>115 U/ml). We enrolled 41 DTC patients with positive TgAb who had undergone total thyroidectomy and subsequent ¹³¹I therapy as well as applied SYT in group 1 (G1). Patients with an interval of more than 6 months between SYT use and ¹³¹I therapy or with repeated TgAb measurements before the use of SYTs were divided into group 2 (G2) and group 3 (G3), respectively. Changes in TgAb after application of SYT in both G1 and G2 were observed and analyzed by rank sum test. Comparison of TgAb gradient over certain time before and after the application was analyzed by t-test. The proportions of patients with decreased or elevated TgAb were 85.4% and 14.6% in G1 and 90.9% and 9.1% in G2, respectively. Compared with the previous TgAb levels, TgAb decreased significantly after the application of SYT in either G1 (P=0.000) or G2(P=0.003). In
ISSN:1000-503X
DOI:10.3881/j.issn.1000-503X.2015.05.017