Synergistic effect and compatibility structure of active anti-inflammatory ingredients from Lamiophlomis rotata based on network pharmacology and component structure theory

• Published in: Zhongguo zhongyao zazhi Vol. 49; no. 13; p. 3505
• Main Authors: Kang, Dian-Dian, Zhang, Rong-Rong, Zhan, Hu-Po, Sun, Jie-Yu, Jiang, Gui-Hua, Jiang, Yun-Bin
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2024
• Subjects: Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Drug Synergism; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Interleukin-6 - genetics; Interleukin-6 - immunology; Interleukin-6 - metabolism; Lamiaceae - chemistry; Male; Mice; Network Pharmacology; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; anti-inflammatory; uniform design; active ingredients; compatibility ratio; network pharmacology; Lamiophlomis rotata

The synergistic effect and compatibility structure of active anti-inflammatory ingredients(iridoid glycosides: shanzhiside methylester and 8-O-acetylshanzhiside methyl ester, flavonoid glycoside: luteoloside, and phenylethanoid glycoside: forsythoside B) from Lamiophlomis rotata were explored based...