Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease

• Published in: Molekuliarnaia biologiia Vol. 58; no. 5; p. 821
• Main Authors: Markelov, V A, Korytina, G F, Aznabaeva, Y G, Gibadullin, I A, Akhmadishina, L Z, Nasibullin, T R, Kochetova, O V, Avzaletdinov, A M, Zagidullin, N Sh
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2024
• Subjects: Aged; Cellular Senescence - genetics; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Oxidative Stress - genetics; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; Transforming Growth Factor beta2 - genetics; long noncoding RNAs; oxidative stress; cell senescence; chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory respiratory disease. The molecular pathogenesis of COPD may include dysregulation of the stress responses that are associated with cell senescence and involve a wide range of signaling pathways and th...