IL-34 and coronary heart disease complicated with diabetes mellitus

Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colo...

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Published inZhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 46; no. 12; pp. 1409 - 1414
Main Authors Liu, Huiqing, Jin, Fengbiao, Li, Qinglian, Gao, Yu, Liu, Xiaoteng, Hou, Ruitian
Format Journal Article
LanguageChinese
English
Published China 28.12.2021
Subjects
Coronary Disease - complications
Diabetes Mellitus, Type 2 - complications
Humans
Inflammation - complications
Insulin Resistance
Interleukins
inflammatory factor
coronary heart disease
diabetes mellitus
mononuclear phagocyte system
interleukin-34
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Summary:Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor, and it is closely related to inflammatory and autoimmune diseases. IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus. IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions, ultimately leading to the occurrence and development of coronary heart disease, type 2 diabetes, and their comorbidities.
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ISSN:1672-7347
DOI:10.11817/j.issn.1672-7347.2021.200797