Matrix metalloproteinases and collagen ultrastructure in moderate myocardial ischemia and reperfusion in vivo

Severe ischemic injury or infarction of myocardium may cause activation of matrix metalloproteinases (MMPs) and damage the interstitial matrix. However, it is unknown whether MMP activation and matrix damage occur after moderate ischemia and reperfusion that result in myocardial stunning without inf...

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 48; no. 2; pp. H601 - H609
Main Authors LI LU, GUNJA-SMITH, Z, WOESSNER, J. F, URSELL, P. C, NISSEN, T, GALARDY, R. E, YA XU, PEILI ZHU, SCHWARTZ, G. G
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.08.2000
Subjects
Biological and medical sciences
Cardiology. Vascular system
Cellular biology
Circulatory system
Coronary heart disease
Enzymes
Heart
Medical sciences
Heart
Cardiac performance
Cardiovascular disease
Metalloendopeptidases
Myocardial disease
Vascular disease
Reperfusion
Enzymatic activity
Ischemia
Ultrastructure
Ungulata
Scanning electron microscopy
Pathophysiology
Enzyme
Coronary heart disease
Gelatinase B
Gelatinase A
Pig
Peptidases
Vertebrata
Mammalia
Animal
Collagen
Myocardium
Hydrolases
Circulatory system
Artiodactyla
Lesion
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Summary:Severe ischemic injury or infarction of myocardium may cause activation of matrix metalloproteinases (MMPs) and damage the interstitial matrix. However, it is unknown whether MMP activation and matrix damage occur after moderate ischemia and reperfusion that result in myocardial stunning without infarction, and if so whether such changes contribute to postischemic myocardial expansion and contractile dysfunction.
ISSN:0363-6135
1522-1539