Application effect of a dual release system of androgen and its antagonist in the repair of full-thickness burn wounds in mice

• Published in: Zhonghua shao shang yu chuang mian xiu fu za zhi Vol. 40; no. 2; p. 180
• Main Authors: Huang, R Z, Wang, Y W, Huang, H Y, Jiang, R H, Xue, N N, Yin, S P, Zhao, H Y
• Format: Journal Article
• Language: Chinese
• Published: China 20.02.2024
• DOI: 10.3760/cma.j.cn501225-20230802-00033
• ISSN: 2097-1109

To explore the optimal ratio of dihydrotestosterone and hydroxyflutamide (hereinafter referred to as DH), construct a dual release system of androgen and its antagonist, and analyze the application effect of this system in the repair of full-thickness burn wounds in mice. This study was an experimental study. The HaCaT cells were divided into blank group (without drug culture), low baseline group, medium baseline group, and high baseline group according to the random number table (the same grouping method below), and the last three groups of cells were cultured by adding three different ratios of DH. Under a medium ratio, the mass of dihydrotestosterone in the three baseline groups from low to high was 1.4, 2.8, and 4.0 µg, respectively, and the mass of hydroxyflutamide was 1.2, 1.6, and 2.0 µg, respectively. On this basis, under a small ratio, the mass of dihydrotestosterone was reduced by half and the mass of hydroxyflutamide was increased by half; under a large ratio, the mass of dihydrotestosterone was in