Molecular and functional identification of sodium channels in K562 cells

• Published in: T͡S︡itologii͡a Vol. 54; no. 7; p. 573
• Main Authors: Sudarikova, A V, Vasil'ev, I O, Morachevskaia, E A, Neguliaev, Iu A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Amiloride - pharmacology; Calcium - metabolism; Cell Membrane - drug effects; Cell Membrane - metabolism; Epithelial Sodium Channels - drug effects; Epithelial Sodium Channels - isolation & purification; Epithelial Sodium Channels - metabolism; Humans; K562 Cells; Magnesium - metabolism; Membrane Potentials - drug effects; Patch-Clamp Techniques; Permeability - drug effects

Modulations of ion channel activity underlie rapid changes in membrane transport of cations in various non-excitable cells. Previously, in smooth muscle cells, macrophages, lymphocytes, carcinoma and leukemia cell lines, non-voltage-gated sodium (NVGS) channels have been found. The activity of NVGS...