Cardiac stem cell therapy for the treatment of chronic stable angina refractory to conventional therapy. State of the art and current clinical experience of the San Raffaele Hospital of Milan, Italy
Cardiac stem cell therapy is a field of scientific research with the goal to translate into clinical benefit the initial findings obtained in basic research laboratories. We have moved into clinical trials in different disease categories: acute myocardial infarction, chronic stable angina refractory...
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Published in | Giornale italiano di cardiologia (2006) Vol. 12; no. 3; p. 198 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | Italian |
Published |
Italy
01.03.2011
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Abstract | Cardiac stem cell therapy is a field of scientific research with the goal to translate into clinical benefit the initial findings obtained in basic research laboratories. We have moved into clinical trials in different disease categories: acute myocardial infarction, chronic stable angina refractory to conventional therapy and heart failure. So far we have faced with contradictory results. Some previous studies suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular function in patients with chronic myocardial ischemia.
In this paper we present a brief review about stem cell use in clinical cardiology and describe our research protocol evaluating the effects of direct intramyocardial injection of autologous bone marrow cells (CD34+ selected cells versus all mononuclear cells) in patients with chronic myocardial ischemia.
Preliminary results show that this procedure seems to be safe and generally well tolerated by patients. An improvement in symptoms, in the first 6 months, appears to be achieved in approximately 50% of patients, with concomitant improvement of quantitative scintigraphic stress test imaging.
Before drawing any definitive conclusions, we need to wait for the end of enrollment and unblinding of study randomization. |
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AbstractList | Cardiac stem cell therapy is a field of scientific research with the goal to translate into clinical benefit the initial findings obtained in basic research laboratories. We have moved into clinical trials in different disease categories: acute myocardial infarction, chronic stable angina refractory to conventional therapy and heart failure. So far we have faced with contradictory results. Some previous studies suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular function in patients with chronic myocardial ischemia.
In this paper we present a brief review about stem cell use in clinical cardiology and describe our research protocol evaluating the effects of direct intramyocardial injection of autologous bone marrow cells (CD34+ selected cells versus all mononuclear cells) in patients with chronic myocardial ischemia.
Preliminary results show that this procedure seems to be safe and generally well tolerated by patients. An improvement in symptoms, in the first 6 months, appears to be achieved in approximately 50% of patients, with concomitant improvement of quantitative scintigraphic stress test imaging.
Before drawing any definitive conclusions, we need to wait for the end of enrollment and unblinding of study randomization. |
Author | Imros, Maria A Condorelli, Gianluigi Godino, Cosmo Ferrari, Angela Briguori, Carlo Samanes Gajate, Ana M Colombo, Antonio Cera, Michela Salomoni, Monica Fragasso, Gabriele Toia, Patrizia Capogrossi, Maurizio C Saolini, Marta Airoldi, Flavio Todeschini, Paola Gianolli, Luigi Oppizzi, Michele |
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DocumentTitleAlternate | La terapia cellulare cardiaca nel trattamento dei pazienti con angina cronica refrattaria alle terapie convenzionali. Excursus sullo stato dell'arte e descrizione dell'esperienza clinica in corso all'Ospedale San Raffaele di Milano |
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SubjectTerms | Aged Angina Pectoris - therapy Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Coronary Circulation Double-Blind Method Female Humans Injections, Intramuscular - methods Length of Stay Male Monocytes - cytology Monocytes - transplantation Myocardial Infarction - diagnostic imaging Myocardial Infarction - therapy Quality of Life Risk Factors Stem Cell Transplantation - methods Tomography, Emission-Computed, Single-Photon Treatment Outcome |
Title | Cardiac stem cell therapy for the treatment of chronic stable angina refractory to conventional therapy. State of the art and current clinical experience of the San Raffaele Hospital of Milan, Italy |
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