Significant regression of glioblastoma with low level of Mgmt gene expression following radiotherapy

• Published in: Voprosy onkologij Vol. 57; no. 2; p. 245
• Main Authors: Matsko, M V, Luchin, E I, Ievleva, A G, Bakholdin, D V, Abysheva, S N, Zavgorodniaia, E V, Potapova, O N, Imianitov, E N, Ulitin, A Iu, Matsko, D E
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2011
• Subjects: Adult; Antineoplastic Agents, Alkylating - therapeutic use; Biomarkers, Tumor - metabolism; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain Neoplasms - radiotherapy; Chemotherapy, Adjuvant; Dacarbazine - analogs & derivatives; Dacarbazine - therapeutic use; DNA Modification Methylases - metabolism; DNA Repair Enzymes - metabolism; DNA, Neoplasm - drug effects; DNA, Neoplasm - radiation effects; Dose Fractionation; Gene Expression Regulation, Neoplastic; Glioblastoma - metabolism; Glioblastoma - pathology; Glioblastoma - radiotherapy; Humans; Magnetic Resonance Imaging; Male; Protons - therapeutic use; Radiotherapy, Adjuvant; Radiotherapy, Conformal - methods; Treatment Outcome; Tumor Suppressor Proteins - metabolism

Radiochemotherapy is leading the universal research effort in fighting lethality: it is improving relapse-free survival of patients with inoperable glioblastoma, the most pernicious brain tumor in adults. Its effectiveness was found to depend on expression of Mgmt gene of tumor DNA reparation follow...