G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis

• Published in: Cell metabolism Vol. 11; no. 4; pp. 320 - 330
• Main Authors: Chen, Min, Chen, Hui, Nguyen, Annie, Gupta, Divakar, Wang, Jie, Lai, Edwin W, Pacak, Karel, Gavrilova, Oksana, Quon, Michael J, Weinstein, Lee S
• Format: Journal Article
• Language: English
• Published: United States 07.04.2010
• Subjects: Acclimatization - physiology; Adipogenesis - genetics; Adipogenesis - physiology; Adipose Tissue - physiology; Animals; Blood Chemical Analysis; Cold Temperature; Diet; Energy Metabolism - physiology; GTP-Binding Protein alpha Subunits, Gs - deficiency; GTP-Binding Protein alpha Subunits, Gs - genetics; Mice; Mice, Transgenic; Muscle, Skeletal - metabolism; Phenotype; Thermogenesis - physiology

G(s)alpha, the G protein that mediates receptor-stimulated cAMP generation, has been implicated as a regulator of adipogenesis and adipose tissue function. Heterozygous G(s)alpha mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients and in mice. In this study, we generated m...