sLea and sLex expression in colorectal cancer: implications for tumourigenesis and disease prognosis

• Published in: Histology and histopathology Vol. 26; no. 10; p. 1305
• Main Authors: Portela, S Villar, Martín, C Vázquez, Romay, L Muinelo, Cuevas, E, Martín, E Gil, Briera, A Fernández
• Format: Journal Article
• Language: English
• Published: Spain 01.10.2011
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenoma - metabolism; Adenoma - pathology; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Disease-Free Survival; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Neoplasm Staging; Oligosaccharides - biosynthesis; Prognosis

The glycoconjugates expressed by cancer cells frequently contain sialylated oligosaccharide chains. Among these oligosaccharides the sialyl Lewis a (sLe(a)) and sialyl Lewis x (sLe(x)) antigens are found to be overexpressed in tumours of different origin. The current study assesses sLe(a) and sLe(x)...