A thermosensitive vaginal gel formulation with HPgammaCD for the pH-dependent release and solubilization of amphotericin B

• Published in: European journal of pharmaceutical sciences Vol. 41; no. 2; pp. 399 - 406
• Main Authors: Kim, Ye-Tae, Shin, Baek-Ki, Garripelli, Vivek Kumar, Kim, Jin-Ki, Davaa, Enkhzaya, Jo, Seongbong, Park, Jeong-Sook
• Format: Journal Article
• Language: English
• Published: Netherlands 09.10.2010
• Subjects: Amphotericin B - administration & dosage; Amphotericin B - chemistry; Calorimetry, Differential Scanning; Female; Gels; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Solubility; Spectroscopy, Fourier Transform Infrared; Vagina; X-Ray Diffraction

To achieve better therapeutic efficacy and patient compliance in the treatment for Candida vaginitis, the antifungal agent amphotericin B (AmB) was formulated in a vaginal gel using Pluronic-based multiblock copolymers (MBCP-2). To increase its aqueous solubility, the drug was incorporated as its in...