Aberrant neuronal expression of mitotic protein, tau and Bax in the rat brain after injection of Abeta(25-35) into the amygdala

• Published in: Sheng li hsüeh pao Vol. 55; no. 2; p. 142
• Main Authors: Hong, Dao-Jun, Pei, Ai-Lin, Sun, Feng-Yan, Zhu, Cui-Qing
• Format: Journal Article
• Language: Chinese
• Published: China 25.04.2003
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Amygdala - drug effects; Amygdala - metabolism; Amygdala - physiopathology; Amyloid beta-Peptides - toxicity; Animals; bcl-2-Associated X Protein - metabolism; Cyclin A - metabolism; Cyclin B1 - metabolism; Male; Neurons - metabolism; Peptide Fragments - toxicity; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; tau Proteins - metabolism

Recent evidence indicates that the aberrant neuronal expression of mitotic proteins in Alzheimer's disease (AD) brain may be related to AD pathological changes. To investigate whether the toxicity of beta-amyloid protein (Abeta) induces mitotic proteins expression in adult rat brain, we used im...