86Rb+ efflux mediated by alpha4beta2-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization

• Published in: Biochemical pharmacology Vol. 80; no. 8; p. 1238
• Main Authors: Marks, Michael J, Meinerz, Natalie M, Brown, Robert W B, Collins, Allan C
• Format: Journal Article
• Language: English
• Published: England 15.10.2010
• Subjects: Acetylcholine - administration & dosage; Acetylcholine - pharmacology; Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Mice; Mice, Inbred C57BL; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - pharmacology; Receptors, Nicotinic - metabolism; Rubidium - metabolism; Synaptosomes - drug effects; Synaptosomes - metabolism

The nicotinic acetylcholine receptors (nAChR) assembled from alpha4 and beta2 subunits are the most densely expressed subtype in the brain. Concentration-effect curves for agonist activation of alpha4beta2*-nAChR are biphasic. This biphasic agonist sensitivity is ascribed to differences in subunit s...