Species difference in cholesterol 7alpha-hydroxylase expression of rabbit and rat liver microsomes after bile duct ligation

• Published in: The Journal of surgical research Vol. 119; no. 1; pp. 36 - 40
• Main Authors: Tanaka, Shun-Ichi, Kinowaki, Mitsuru, Maeda, Yorio, Nagatomo, Junji, Kai, Masa-Hiro, Kondo, Kazu-Hiro, Chijiiwa, Kazuo
• Format: Journal Article
• Language: English
• Published: United States 01.06.2004
• Subjects: Animals; Bile Acids and Salts - blood; Bile Ducts - surgery; Bilirubin - blood; Cholesterol - blood; Cholesterol 7-alpha-Hydroxylase - genetics; Cholesterol 7-alpha-Hydroxylase - metabolism; Ligation; Male; Microsomes, Liver - enzymology; Osmolar Concentration; Rabbits; Rats; Rats, Wistar; RNA, Messenger - metabolism; Species Specificity

Bile duct ligation (BDL) produces a good animal model for investigation of the metabolic changes in obstructive jaundice. The aim of this study was to investigate the species difference in expression of cholesterol 7alpha-hydroxylase (7alpha-hydroxylase) in rabbits and rats after BDL. Ten male New Z...