17beta-estradiol regulates constitutive nitric oxide synthase expression differentially in the myocardium in response to pressure overload

• Published in: Endocrinology (Philadelphia) Vol. 148; no. 10; pp. 4579 - 4584
• Main Authors: Loyer, Xavier, Damy, Thibaud, Chvojkova, Zuzana, Robidel, Estelle, Marotte, Françoise, Oliviero, Patricia, Heymes, Christophe, Samuel, Jane-Lise
• Format: Journal Article
• Language: English
• Published: United States 01.10.2007
• Subjects: Animals; Aorta, Thoracic; Caveolin 1 - metabolism; Constriction; Echocardiography; Estradiol - metabolism; Estradiol - pharmacology; Female; Heart - drug effects; Heart - physiopathology; Hypertension - metabolism; Hypertension - physiopathology; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - metabolism; Hypertrophy, Left Ventricular - physiopathology; Immunoprecipitation; Myocardium - metabolism; Nitric Oxide Synthase Type I - metabolism; Nitric Oxide Synthase Type III - metabolism; Ovariectomy; Rats; Rats, Wistar

Estrogens [E(2)] exert direct and indirect effects that can modulate the development of cardiac disease. However, the precise mechanisms that are involved remain undefined. Our objective was to investigate whether E(2) affected the activity and expression of constitutive nitric oxide synthase (NOS)...