Use of a novel hepato-protective preparation "phospholiv" for inhibition of development of chronic hepatitis in rats

Protective influence of a new phospholipid preparation "Phospholiv" was studied using a model of chronic hepatitis. Animals were treated 45 days intraperitoneay with CCl4 with parallel intragastral administration of Phospholiv or--(for comparison)--the of other phospholipid hepatoprotector...

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Published inVoprosy meditsinskoi khimii Vol. 44; no. 6; p. 537
Main Authors Ipatova, O M, Torkhovskaia, T I, Kniazhev, V A, Karuzina, I I, Bachmanova, G I, Guseva, M K, Archakov, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1998
Subjects
Animals
Carbon Tetrachloride Poisoning - metabolism
Carbon Tetrachloride Poisoning - pathology
Carbon Tetrachloride Poisoning - prevention & control
Chemical and Drug Induced Liver Injury, Chronic - metabolism
Chemical and Drug Induced Liver Injury, Chronic - pathology
Chemical and Drug Induced Liver Injury, Chronic - prevention & control
Drug Combinations
Glycyrrhizic Acid - analogs & derivatives
Glycyrrhizic Acid - therapeutic use
Hepatitis, Animal - metabolism
Hepatitis, Animal - pathology
Hepatitis, Animal - prevention & control
Liver - metabolism
Liver - pathology
Male
Phosphatidylcholines - therapeutic use
Protein Biosynthesis
Rats
RNA - biosynthesis
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Summary:Protective influence of a new phospholipid preparation "Phospholiv" was studied using a model of chronic hepatitis. Animals were treated 45 days intraperitoneay with CCl4 with parallel intragastral administration of Phospholiv or--(for comparison)--the of other phospholipid hepatoprotector, Essential. Morphologic changes of liver, as well as protein and RNA biosynthesis were evaluated in the end of experiment--by means of measuring C14-leucine and C14-orotic acid incorporation into hepatocyte subcellular fractions. Both phospholipid preparations attenuated dystrophic liver changes, Phospholiv effect being more pronounced. They both prevented CCl4 induced inhibition of label incorporation into subcellular fraction proteins, but only Phospholiv, promoted the maintaining normal level of radioactivity incorporation into cytosol proteins and hepatocyte RNA. The results, confirming certain protective effect of Essential, show more pronounced hepatoprotective action of the new preparation Phospholiv (developed on the basis of polyunsaturated phosphatidylcholine and glycyrrhizinic acid salt). Data show also on possible fit hepatitis treatment.
ISSN:0042-8809