Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene

• Published in: The journal of clinical endocrinology and metabolism Vol. 87; no. 2; p. 772
• Main Authors: Hara, Manami, Alcoser, Sergio Y, Qaadir, Arshia, Beiswenger, Kristina K, Cox, Nancy J, Ehrmann, David A
• Format: Journal Article
• Language: English
• Published: United States 01.02.2002
• Subjects: Adult; Alleles; Amino Acid Sequence - genetics; Asian People - genetics; Black or African American; Black People - genetics; Body Mass Index; Fasting - blood; Female; Glucose Tolerance Test; Heterozygote; Humans; Insulin - blood; Insulin Resistance - physiology; Polycystic Ovary Syndrome - ethnology; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - pathology; Polycystic Ovary Syndrome - physiopathology; Polymorphism, Genetic - genetics; Receptors, Cytoplasmic and Nuclear - genetics; Transcription Factors - genetics; White People - genetics

Polycystic ovary syndrome (PCOS) is common in women of reproductive age and is associated with a high risk for development of type 2 diabetes. Insulin resistance, a key component in the pathogenesis of PCOS and glucose intolerance, is ameliorated by the thiazolidinediones, synthetic ligands for the...