RNA editing of interleukin-12 receptor beta2, 2451 C-to-U (Ala 604 Val) conversion, associated with atopy

• Published in: Clinical and experimental allergy Vol. 34; no. 3; p. 363
• Main Authors: Kondo, N, Matsui, E, Kaneko, H, Aoki, M, Kato, Z, Fukao, T, Kasahara, K, Morimoto, N
• Format: Journal Article
• Language: English
• Published: England 01.03.2004
• Subjects: Case-Control Studies; Cells, Cultured; Chi-Square Distribution; Child; Down-Regulation; Electroporation; Flow Cytometry; Gene Conversion; Humans; Hypersensitivity, Immediate - immunology; Immunoglobulin E - immunology; Interferon-gamma - immunology; Interleukin-12 - immunology; Receptors, Interleukin - genetics; Receptors, Interleukin-12; RNA Editing; RNA, Messenger - analysis; Sequence Analysis, DNA; Signal Transduction; Statistics, Nonparametric; Transfection - methods

The production of IgE in B lymphocytes is down-regulated by IFN-gamma. IL-12 induces IFN-gamma production by T lymphocytes and natural killer cells by binding to its specific receptor. RNA editing is a post-transcriptional modification. Here we show that the RNA editing of IL-12 receptor (R) beta2 i...