Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages

• Published in: The Journal of biological chemistry Vol. 280; no. 26; p. 24347
• Main Authors: Liu, Jianguo, Guan, Xiuqin, Ma, Xiaojing
• Format: Journal Article
• Language: English
• Published: United States 01.07.2005
• Subjects: Adenoviridae - genetics; Amino Acid Motifs; Animals; Base Sequence; Blotting, Western; CD4 Antigens - biosynthesis; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus - metabolism; Cell Transformation, Neoplastic; Chemokine CCL5 - metabolism; Chemokines, CC - metabolism; Chemotaxis; Chromatin Immunoprecipitation; DNA, Complementary - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Interferon Regulatory Factor-1; Interferon-gamma - metabolism; Lipopolysaccharides - chemistry; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Mutagenesis; Phosphoproteins - genetics; Phosphoproteins - physiology; Plasmids - metabolism; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases - metabolism; RNA, Messenger - metabolism; Sequence Homology, Nucleic Acid; Time Factors; Transcriptional Activation; Transfection

Interferon regulatory factor 1 (IRF-1) is an important transcription factor in interferon gamma (IFNgamma)-mediated signaling in the development and function of NK cells and cytotoxic T lymphocytes. RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member of the CC che...