The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes

• Published in: Endocrinology (Philadelphia) Vol. 147; no. 4; p. 1685
• Main Authors: Tao, Yukari, Maegawa, Hiroshi, Ugi, Satoshi, Ikeda, Kazuhiro, Nagai, Yoshio, Egawa, Katsuya, Nakamura, Takaaki, Tsukada, Shuichi, Nishio, Yoshihiko, Maeda, Shiro, Kashiwagi, Atsunori
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: 3T3-L1 Cells; Adipocytes - metabolism; Adipocytes - pathology; Animals; DNA - metabolism; Glucose - metabolism; Glucose Transporter Type 4 - metabolism; Hypertrophy; Insulin Resistance; Lipid Metabolism; Mice; Phospholipase C gamma - physiology; Phosphoproteins - metabolism; Protein Kinase C - physiology; Protein Transport; Transcription Factor AP-2 - physiology; Type C Phospholipases - physiology

We have reported the association of variations in the activating protein-2beta (AP-2beta) transcription factor gene with type 2 diabetes. This gene was preferentially expressed in 3T3-L1 adipocytes in a differentiation stage-dependent manner, and preliminary experiments showed that subjects with the...