Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects

• Published in: European archives of psychiatry and clinical neuroscience Vol. 259; no. 5; p. 284
• Main Authors: Roser, Patrik, Gallinat, Jürgen, Weinberg, Gordon, Juckel, Georg, Gorynia, Inge, Stadelmann, Andreas M
• Format: Journal Article
• Language: English
• Published: Germany 01.08.2009
• Subjects: Administration, Oral; Adult; Analysis of Variance; Cannabidiol - administration & dosage; Cannabidiol - pharmacology; Cannabinoids - administration & dosage; Cannabinoids - pharmacology; Cannabis - chemistry; Cross-Over Studies; Double-Blind Method; Dronabinol - administration & dosage; Dronabinol - analogs & derivatives; Dronabinol - blood; Dronabinol - metabolism; Dronabinol - pharmacology; Female; Fingers - physiology; Functional Laterality - drug effects; Humans; Male; Neuropsychological Tests; Plant Preparations - chemistry; Plant Structures - chemistry; Psychomotor Performance - drug effects; Reference Values

Abnormalities in psychomotor performance are a consistent finding in schizophrenic patients as well as in chronic cannabis users. The high levels of central cannabinoid (CB(1)) receptors in the basal ganglia, the cerebral cortex and the cerebellum indicate their implication in the regulation of moto...