Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 35; p. 14978
• Main Authors: Porta, Chiara, Rimoldi, Monica, Raes, Geert, Brys, Lea, Ghezzi, Pietro, Di Liberto, Diana, Dieli, Francesco, Ghisletti, Serena, Natoli, Gioacchino, De Baetselier, Patrick, Mantovani, Alberto, Sica, Antonio
• Format: Journal Article
• Language: English
• Published: United States 01.09.2009
• Subjects: Animals; Cell Polarity; Cells, Cultured; Endotoxins - pharmacology; Humans; Immune Tolerance; Interferon-beta - biosynthesis; Lipopolysaccharides - pharmacology; Macrophages - cytology; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Knockout; NF-kappa B p50 Subunit - deficiency; NF-kappa B p50 Subunit - metabolism; STAT1 Transcription Factor - metabolism

Cells of the monocyte-macrophage lineage play a central role in the orchestration and resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response to environmental signals these cells undergo different forms of polarized activation, the extremes of which are called...